Symbol
Name
ID

Trp53
transformation related protein 53
MGI:98834

Phenotype annotations related to digestive/alimentary system

Darker colors indicate more annotations

Human Phenotypes

Neoplasm of the rectum

Colorectal polyposis

Adenocarcinoma of the colon

Hereditary nonpolyposis colorectal carcinoma

Adenomatous colonic polyposis

Colon cancer

Intestinal pseudo-obstruction

Neoplasm of the stomach

Stomach cancer

Intermittent diarrhea

Nausea and vomiting

Nausea

Vomiting

Functional abnormality of the gastrointestinal tract

Functional intestinal obstruction

Neoplasm of the liver

Hepatocellular carcinoma

Neoplasm of the gastrointestinal tract

Adenocarcinoma of the small intestine

Disease(s) Associated with TP53

choroid plexus papilloma

colorectal cancer

hepatocellular carcinoma

Li-Fraumeni syndrome

Li-Fraumeni syndrome 1

mismatch repair cancer syndrome

multiple myeloma

pancreatic cancer

stomach cancer

Mouse Phenotypes

decreased enterocyte apoptosis

increased enterocyte apoptosis

oral leukoplakia

cleft palate

abnormal tongue morphology

protruding tongue

intestinal ulcer

colon polyps

intestine polyps

gastric polyps

increased intestinal adenoma incidence

Availability

Mouse Genotype

Trp53^tm1.1Tldo/Trp53^tm1.1Tldo

Trp53^tm1.2Awbr/Trp53^tm1.2Awbr

Trp53^tm1Mlh/Trp53^tm1Mlh

Trp53^tm1Tyj/Trp53^tm1Tyj

Trp53^tm1.2Awbr/Trp53⁺

Trp53^tm1Brd/Trp53^tm8Xu

Trp53^tm1Tyj/Trp53⁺

Tg(CMV-cre)1Cgn/0
Trp53^tm4Att/Trp53⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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